Hi, I’m Paul Tran

MD/PhD Student, Aspiring Triathlete, Outdoor Enthusiast, Father of Cats


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My name is Paul Minh Huy Tran. I am a second generation Vietnamese American. I am an 8th year MD/PhD student at Augusta University.

I completed my PhD dissertation titled “APPLICATIONS OF MACHINE LEARNING TO GENOMICS: STUDIES IN TYPE 1 DIABETES AND CANCER” in Spring 2020 from the lab of Jin-Xiong She, PhD.

I live with my mother, sister, sister’s dog (“Nhan”, born October 12, 2019).

My partner and I take care of three fur babies. They are Paul Jr (born July 31, 2021), Luna (born August 20, 2020); and George (born May 7, 2014).

My grants and publications are listed here

  • I have a twin sister who is also an MD/PhD student at Augusta University
  • I have traveled to all 50 states in the US
  • I started medical school at 17
  • I don’t drink coffee
  • I was a drum major in high school. Watch my band perform circa 2012!

My Life In Pictures

I did science from a young age


Latest Post

Jan 16, 2021

My Study Resources for Clinical Rotations and Step 2

Internal Medicine (4 weeks) Shortened by 2 weeks because of COVID Uworld Anki (Cheesy Dorian and Zanki Step 2) OME Pre-test Case files Family Medicine (6 weeks) AAFP questions Anki Cheesy Dorian Pre-test Dr. High Yield Pediatrics (6 weeks) Uworld Anki Cheesy Dorian Case files Emma Holliday Psychiatry (3 weeks) Uworld Anki Cheesy Dorian Emma Holliday Dr. High Yield Neurology (3 weeks) Uworld Anki Cheesy Dorian Surgery (6 weeks) Uworld Anki Cheesy Dorian OME OBGYN (6 weeks) Uworld Anki Cheesy Dorian OME Retake Neurology? Read more

All Posts


  • Jan 16, 2021 - My Study Resources for Clinical Rotations and Step 2
  • 2020

  • Nov 6, 2020 - Genetic risk of islet autoimmunity
  • 2018

  • Nov 6, 2018 - Pipetting Practice for Rotating and Summer Students
  • 2017

  • Nov 1, 2017 - Sapelo Island Field Research Summer 2013
  • 2015

  • Nov 13, 2015 - Ultrasound-Guided Mouse Xenograft

  • Research Contributions

    I worked on two microbiology research during my undergraduate training at the University of North Georgia, Dahlonega Campus.

    Antibiotic Resistance mechanisms of the gut microbe Bacteroides spp. (2012-2014)

    I studied a putative tripartite efflux pump with high homology to the well studied E. coli AcrE-AcrF-TolC pump by using perform genetic complementation and drug susceptibility assays. This work was performed under the mentorship of Paul Johnson, PhD.


    Abundance and Diversity of Halophiles on the salt pans of Sapelo Island (2013)

    Two of my classmates and I traveled to Sapelo Island, GA to explore the halophiles on the salt pans of sapelo island. We found that higher salinity salt pans are usually further away from freshwater and that the higher salinity salt pans have both high abundance and diversity of halophiles! This work was performed under the co-mentorship of Nancy Dalman, PhD and Paul Johnson, PhD. Links:

    Abstract, Local Poster Presentation, see my blog post about my experience on Sapelo Island!

    Post-transcriptional regulation of csrA through the FliW chaperone protein in Campylobacter jejuni (2014)

    I rotated in the laboratory of Stuart Thompson, PhD. We studied with role of the chaperone protein FliW in regulating the transcription factor csrA in Campylobacter jejuni. This transcription facter plays a critical role in biofilm formation in Campylobacter spp.

    Manuscript 1

    During my early years in medical and graduate school, I applied machine learning methods to genomics data to help with classification and predicting poor prognosis in various cancers. I formulated the project and conducted all of the brain cancer project. For the gynecologic cancer projects, I was involved in patient consent, specimen collection, sample processing, data curation, data analysis, and manuscript writing.

    Transcriptomic Classification of Gliomas

    This project is a major part of my thesis. I used publicly available glioma transcriptomic data and applied a custom unsupervised classification algorithm using a combination of UMAP and density-based clustering. I identified four clusters highly similar to previously published IDH-codel groups and methylomic groups. The new clusters may better reflect patient survival compared to previously reported glioma groups. I validated these findings in a local retrospective cohort.

    Manuscript 1, AACR 2019 Poster Presentation, news article, and local news channel feature

    Manuscript 2 and Code

    Serum markers of Poor Prognosis in a Peruvian Cervical Cancer Cohort

    In this project, I helped analyze data from the Cervicusco project head by Daron Ferris, MD. We wanted to identify serum markers of poor prognosis that could be used in the low resource settings in Peru.

    The first manuscript identifies anti-carbohydrate antibodies (ACAs) using a custom array developed by Sharad Purohit, PhD and my mentor, Jin-Xiong She, PhD. Manuscript

    The second manuscript identifies serum proteins detected on a muliplex immunoassay associated with poor prognosis. Manuscript

    During my later years in graduate school, I applied machine learning methods to genetic, clinical, and serum protein data to help with predicting islet autoimmunity and diabetic complications.

    Polygenic Risk Score for Islet Autoimmunity

    I was fortunate to receive funding from the NIH for the type 1 diabetes work. The work focuses on data generated from the TEDDY consortium, of which my PhD mentor, Dr. Jin-Xiong She, is a PI.

    A manuscript detailing the polygenic risk of islet autoimmunity in newborns is in preparation. News article feature

    See my blog post on the difference between a PRS for islet autoimmunity compared to type 1 diabetes and why it is more important to predict islet autoimmunity here.

    Genetic Mapping of Type 1 Diabetes Associated Variants

    We a have identified potential causal variants and regulatory mechanism linking the CCR2 locus to type 1 diabetes. Our data suggest that certain variants increase CCR2 gene expression in monocytes and effector T cells leading to increase CCR2/CCL2 pathway activation and immune destruction of pancreatic islets.

    The 3p21.31 genetic locus promotes progression to type 1 diabetes through the CCR2/CCL2 pathway

    A manuscript detailing the genetics of serum Il1-ra and its association with progression to T1D is in progress. code

    The Serum Anti-Carbohydrate Antibody (ACA) Repertoire in Type 1 Diabetes We profiled serum ACAs against 202 glycans from 22 functional clasess in 688 T1D and control subjects from 2 clinical cohorts (PAGODA and DAISY). The manuscript will be submitted soon.


    Type 1 Diabetes Complications

    This project is part of the Phenome and Genome of Diabetic Autoimmunity ( PAGODA) study initiated by my mentor, Jin-Xiong She, PhD through funding from NIDDK and JDRF.

    The first manuscript describes the role of the modifiable risk factors, blood pressure and glucose level, in developing microvascular complications of type 1 diabetes. Links: Code, Website, and Manuscript 1

    The second manuscript describes the role of inflammatory proteins in developing diabetic peripheral neuropathy. Manuscript 2 Code will be released soon.


    I was a mentor to undergraduate, graduate, and medical students during my summers in graduate school.

    trainee project current position
    Caitlyn Hodges Urine proteomic markers for diagnosis of urologic cancers General Surgery Resident, Pennsylvania
    Katherine P Richardson IL1RA knockout NSG mice have a higher rate of islet autoimmunity MPH Student
    Dakota Booth Transcriptomic Classification of Gliomas MD/PhD Student, Augusta University
    Emily Myers Network Analysis of Uterine Serous Carcinoma General Surgery Resident, Colorado University
    Eileen Kim Serum Markers of Diabetic Peripheral Neuropathy Internal Medicine Resident, Rutgers University
    Khaled bin Satter Molecular Classification of Renal Cancers PhD Student, Augusta University
    Chase Wehrle Gene Expression Progostic Signatures in Lung Adenocarcinoma General Surgery Resident, Cleveland Clinic

    Movies and TV Shows I am currently watching

    Ted Lasso

    The Wheel of Time

    The West Wing


    Click here to see my CV.


    My current local time is .